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296,298 One case report described the benefit of SAMe in a 32 year old patient with anxiety who was found to have a MTHFR gene mutation: treatment with methylated B 12 and folate was not effective for relieving symptoms until SAMe, 400 mg twice daily, was added

W., Erichsen, L., Francisco-Ziller, N., Pavia, M., Mikkelsen, P

doi: 10.62110/sciencein.jist.2024.v12.753 8 SenguptaPRoychoudhurySNathMDuttaS

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In addition, VD administration could activate the endogenous target factor silent mating type information regulation 2 homolog-1 (SIRT1), reducing transcriptional activity, and then inhibit NF-B pathway-mediated neuroinflammation, as well as down-regulating the expression of the downstream signaling molecules TNF- and IL-1 [61]

A combination can be scientifically interesting and still remain unapproved for human use