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The primary role of the BBB is to control the flow of substances between the blood and the central nervous system according to the physiological needs of the brain

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Secretome is a collection of substances such as hyaluronic acid, collagen, and growth factors, that cells release into their surroundings

Melatonin supplementation decreases hypertrophic obesity and inflammation induced by high-fat diet in mice

More critically, in colorectal and breast cancer xenograft models, tumor cells activate this IL-8-dependent pathway by releasing lactate via MCT4, which promotes neovascularization and tumor growth

[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Rokutan K