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GSH is enzymatically converted to its oxidized form, glutathione disulfide (GSSG)

In addition, PrfA thiols may be reversibly oxidized, temporarily inactivating the protein by inhibiting DNA binding and leading to a downregulation of PrfA-regulated genes (PRG)

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doi: 10.1016/0014-4800(71)90020-7

[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Runtuwene J., Cheng K.-C., Asakawa A., Amitani H., Amitani M., Morinaga A., Takimoto Y., Kairupan B.H.R., Inui A