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FP802 is a TwinF interface inhibitor that alleviates glutamate neurotoxicity mediated by extrasynaptic NMDARs (eNMDARs) by disrupting the NMDAR/TRPM4 complex, but does not affect the normal physiological function of synaptic NMDARs [78]

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Jiang Y., Jin M., Chen J., Yan J., Liu P., Yao M., Cai W., Pi R

Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, et al

The spRNAs such as calmegin (Guyonnet et al., 2009

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Inflammation-Immunity (Top Left): CP/CPPS triggers a local and systemic cytokine storm characterized by elevated pro-inflammatory cytokines (TNF-, IL-1, IL-6, IL-8), immune cell infiltration, Th17/Treg imbalance, and the production of antisperm antibodies (AsAb)