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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation

Importantly, N-O bond of the dihydroisoxazole (DHI) ring is highly electronegative and contributes to the polarization of the C3-C2 bond, and the C3 imino carbon features a positive electrostatic profile (numbering shown in Figure 2D)

J Immunol (2006) 176:462231

Depending on the cytokine and the context, this can result in release of other types of cytokines, activation of immune cells, recruitment of immune cells to sites of infection or injury, or suppression of immune activity to maintain balance

A study on uterine fibroid cells revealed that a key component of this pathway involves the overexpression of NOX4, leading to excessive ROS production [72]

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