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The thiol system includes the low molecular-weight thiol/disulfide couples such as glutathione (GSH/GSSG) and cysteine/cystine [7], and the oxidized/reduced states of redox enzymes that have cysteine residues at their active sites such as thioredoxins, glutaredoxins, and peroxiredoxins [8]

Cancer Science

In addition, if melatonin is used in combination with hypothermia, the neuroprotective effects are greater than hypothermia alone 134,141,142,143,144,145,146

Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts