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In addition to the endogenous cellular pathways, recent studies have also investigated the role of the gut microbiome in affecting NAD + levels

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Supplementing with vitamin B12 lowers homocysteine levels and may improve mood, particularly in response to stress

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The dose of vitamin B12 used in the VISP and NORVIT trials and issues with the design of the VISP trial might have obscured a small but still meaningful benefit to vitamin B12 supplementation (234)
