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In addition, there are other research attempts, such as hypoxic or pentosan polysulfate pretreatment of mesenchymal cells (Ejtehadifar et al., 2015), co-culture of BMSCS and MECs (Zhang et al., 2018) and use of ADSCs to construct scaffold-free tissue engineering (ADSC-TEC) (Ishiguro et al., 2019)

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Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells

However, these are all speculative applications without any human trial evidence as of 2026