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For cretinism in iodine-deficient areas, Se supplementation should not be promoted prior to iodine supplementation or when there is no plan for iodine supplementation, as stated by the American Thyroid Association, The differential intakes of iodine, Se, or both in different regions must be considered before any action for Se supplementation is taken ( 3.4 Se and thyroid tumors The incidence of thyroid cancer has been on the rise in the past decades, increasing faster than any other cancer ( In addition to increasing the risk of disease, Se deficiency is also strongly associated with the progression of thyroid cancer

A bacterial metabolite, trimethylamine N-oxide, disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice

Marketed as a fat burner and energy booster, L-Carnitine is one of the most popular ingredients in weight management supplements

Carnitine supplementation, independently of its conversion to TMAO, has been associated with several adverse effects, particularly when consumed in excess

The insidious disease progression presents substantial clinical challenges, as approximately 2040% of NAFLD patients may develop non-alcoholic steatohepatitis (NASH) over several years (1, 2), which can subsequently advance to liver fibrosis and HCC (3)