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Type 2: cytotoxic reactions

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A vicious cycle is thereby established, which contributes to the exacerbation of CI (Figure 1)

42 Drug induction mechanism The second aspect is induced transformation which refers to the ability to resist treatment and withstand external drugs, environmental stresses, and other factors

Comparison between studies identified 52 proteins as significant in two or more studies, which were then enriched for 22 pathways, including those previously implicated in PE such as hemostasis, immune response, and lipid metabolism