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In consideration of neuroinflammation-related mechanisms and research methods, the following recommendations emerge: The relationship of ME/CFS to neuroinflammation is a fundamental question that needs to be directly addressed from multiple research angles

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However, while HDAC6 inhibition reduced oxidative damage and preserved cartilage in mouse models and TBHP-treated chondrocytes, the spontaneous and slowly progressive nature of human osteoarthritis is not fully captured in these systems

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