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And it may have direct effects on metabolic rate, though this is still being studied

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198 The APC gene was first identified as a mutated gene in familial adenomatous polyposis coli (FAP)

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have explained a different mechanism of increased barrier permeability, where MMP-9 is implicated in the activation of myosin light chain kinase (MLCK), an enzyme responsible for the phosphorylation of myosin light chain (MLC), a regulator of perijunctional actinomyosin contractility