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This binding activates the expression of key antioxidant genes, including heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and NAD(P)H quinone oxidoreductase 1 (NQO1) ( Figure 3 ) (58, 59)

The standard GHK-Cu (copper tripeptide-1) dose is 1 to 2 mg subcutaneously once daily, five days per week, in cycles of 4 to 12 weeks

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By viewing the metastatic process as an opportunity of interrogating the metabolic profiles of transformed cells when they are at the most fragile moment regarding anabolism and redox sensitivity, it is possible to achieve the aim of survival with tumors by killing malignant cells undergoing the metastasis cascade or permanently attracting them to the quiescence state

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