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In summary, the VIP system is altered in peripheral immune cells of GD patients and this finding is associated with different thyroid hormone receptor patterns, showing a dynamic inter-regulation and a prominent role of VIP in this setting
10.1111/j.1365-2265.1989.tb01260.x Clin
doi: 10.1016/j.molimm.2018.08.008 85 YinHZhangSShenMZhangZHuangHZhaoZet al
PLoS One 13 , e0203084 (2018)
The least clear morphologic expression is selective neuronal necrosis
Notably, these transitions may involve abrupt conformational changes in key target proteins
