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The authors describe cases where the only visible symptoms were persistent, non-itchy hyperpigmented patches or polymorphic skin lesions
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What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect
Claims of meaningful human fat loss should therefore be read as unproven hypotheses , not established outcomes
