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In vertebrates, the majority of enteric neurons and glia develop from neural crest cells originating from the vagal level of the neural tube which invade the foregut and rostro-caudally migrate culminating in the quasi-uniform colonization of the gastrointestinal tract [5, 6]

10.1016/j.biopha.2021.111266 144

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However, the majority of the scientific literature remains preclinical, meaning most studies have been conducted in animal models rather than human clinical trials

doi: 10.1038/s41564-018-0337-x 101 BoQTianLLiFMaoZWangZMaXet al

This is the ladder documented in the Wegovy prescribing information and mirrored in the STEP trial program