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Furthermore, oral administration of KPV reduces the incidence of colitis induced by dextran sulfate sodium (DSS) and 2,4,6-trinitrobenzene sulfonic acid (TNBS), highlighting its potential as a research compound in the context of inflammatory bowel disease (IBD)

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For patients with severe hepatic impairment (Child-Pugh Class C) , Esomeprazole metabolism is significantly reduced and plasma concentrations are substantially elevated
