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For example, the ionic interaction formed between the negatively charged head group of the fatty acid and the sidechain of Arg122 is absent in our structure and is instead satisfied by a malonate ion originating from the crystallization solution

10.1016/B978-0-444-62619-6.00010-0 Handbook of Clinical Neurology 23 ChowB

HDV significantly increased the resistance to toxic effects of oxidants such as hydrogen peroxide (H 2 O 2 ), tert-butyl hydroperoxide (tBHP) and cumene hydroperoxide (data not shown

However, EGFR inhibitors are mostly ineffective in the treatment of TNBC patients, and increasing evidence supports that autophagy is currently related to the drug resistance of EGFR inhibitors in the treatment of TNBC

Clinical trial safety

They are naturally produced in the body when cells are metabolized