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Two main limitations should be mentioned

7-8 As back pain becomes more chronic, the multifidus continues to atrophy and fill with fatty infiltration, requiring intentional treatment for improvement

Self-administered nicotine suppresses body weight gain independent of food intake in male rats

Inhibiting related enzymes such as fatty acid desaturase 2 (FADS2) and acetyl-CoA carboxylase (ACC) confers resistance to lipid peroxidation and ferroptosis induced by the compound RSL3 [38, 39]

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