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[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Mir S.A., Dar B.N., Shah M.A., Sofi S.A., Hamdani A.M., Oliveira C.A., Sant'Ana A.S

Collectively, these data indicate that combined loss of PHD2 and GSTP1 precipitates a metabolic and apoptotic collapse consistent with a synthetic lethal interaction

N., Bhalla, V

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Additionally, berberine, an alkaloid found in several plants including goldenseal and barberry, further supports SIRT1 activation through its ability to induce NAD + biosynthetic pathways and improve metabolic health 180