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With topicals, its all about how much active ingredient is in each drop

(The standard route for this molecule is oral

2013;8:e76808

A recent work exploiting the antitumor activity and mechanism of the Cu(I)-based mitochondria-targeting therapy reported that a mitochondria-targeting Cu(I) complex, namely Cu(I)Br(PPh3)3 (CBP), exhibited antitumor and antimetastatic efficacy both in vitro and in vivo by specifically targeting mitochondria and inducing mitochondrial dysfunction
(Sun et al., 2022) illustrated that NNMT knockdown in a low-glucose environment enhanced the NAD + /NADH ratio in U251 glioma cells

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