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In 1975, Riggs (25) and Holliday and Pugh (26) proposed a scheme by which DNA methylation patterns at CpG dinucleotides could be restored in newly synthesized DNA after DNA replication

This CaCN-NFAT activated way inhibiting the canonical Wnt signalling pathway is covered in our reconstructed network (Saneyoshi et al., 2002, Veeman et al., 2003, Pandur, 2005)