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Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism

Experiments in vitro showed that ezrin regulates extension of astrocytic philopodia (analogs of leaflets), while in situ astrocytic ezrin expression follows circadian changes in glutamatergic transmission, thus changing synaptic coverage 423

Although not explicitly indicated in these studies, we speculate that these interventions exerted their protective effects on fat grafts by inhibiting ferroptosis

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