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In a previous study, we have reported that KEAP1 mutant tumors respond to CB-839 treatment, while growth of wild type tumors is unaffected in vivo (Romero et al., 2017)

Hopefully, in the near future, through the convergence of related disciplines, the development of nanotoxicity research will be significantly promoted, thereby making the application of metal-based NPs in humans much safer

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Nevertheless, most of the studies are based on animal models, and more well-designed clinical trials are required to address the potential of these ingredients when regulating intestinal barrier dysfunctions

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