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Further, for poorly water-soluble drugs and biopharmaceuticals, such as proteins and peptides, powder formulations facilitate the formulation of larger drug doses by co-formulating using excipients that act as bulking agents (water-soluble fillers: lactose, trehalose, mannitol, and sorbitol
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[PubMed] [Google Scholar] 15.Van Meerbeke S., Fajt M

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Were they simultaneous to conventional