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For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank

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This study was approved by the Children's Hospital Los Angeles Institutional Review Board

In a study using the gold-standard experimental model of polymicrobial sepsis, the cecal ligation and puncture (245), metabolic analysis of plasma and urine identified 14 plasma and 11 urine metabolites related to central carbon and choline metabolism (including choline, betaine, methylamine, and creatinine)

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