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Serum MMA may also be elevated in thyroid disease, bacterial overgrowth in the small intestine, pregnancy, or a rare genetic disorder in infants called methylmalonic acidemia
This occurs by the activation of signal transduction pathways involved in the control of transcription of GCLC and GCLM genes but also there is some evidence of mRNA stabilization by oxidants and electrophiles (Liu et al., 1998)
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The other mimics gut hormones that control hunger and insulin
