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Detection of 2HG from body fluids would enable less invasive diagnosis of IDH-mutant gliomas and longitudinal assessment of treatment response in these tumors

Pajaud J, Kumar S, Rauch C et al (2012) Regulation of signal transduction by glutathione transferases

The oncometabolites are produced by mutations in the nuclear-encoded TCA enzymes, isocitrate dehydrogenase 1 and 2 (IDH1/2), succinate dehydrogenase (SDH), and fumarate hydratase (FH) (177)
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Nervous System Support B12 is required for the formation of myelin, which is the protective sheath surrounding the nerve cells (neurons)

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