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Specifically, we identified that the novel polysulfide donor PSCP preserves mitochondrial function in diabetic retinopathy by upregulating isocitrate dehydrogenase (NADP(+)) 2 (IDH2) and microsomal glutathione S-transferase 1 (MGST1) via the Keap1-Nrf2 pathway ( 3.1.2.4 Unresolved questions: pathway crosstalk and donor specificity Critical gaps persist: How do NF-B and Nrf2 pathways coordinate temporally, and what molecular features determine donor-specific cysteine targeting

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In the AKI mouse model built in present study, the BUN and serum MDA levels markedly increased, marked glomerular damage occurred and it was demonstrated that the RGSH intervention could alleviate these effects, which demonstrated the protective effect of RGSH in AKI

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Magnesium increases insulin-dependent glucose uptake in adipocytes

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Other sources of stress besides health challenges may be finances, relationships, work, the death of a loved one, and other life stresses

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Sci Rep 7(1):530

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Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins for viral infection control, encompassing numerous potential drugs and thousands of patients participating in clinical trials

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