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Results showed that the ingredient significantly increased NAD+ levels in senescent fibroblasts, activated the SIRT1 signaling pathway, reduced the expression of senescence-associated -galactosidase (SA--gal), decreased intracellular reactive oxygen species accumulation, and promoted collagen synthesis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Bai P et al

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Users who have achieved significant results may choose to continue at a maintenance dose, take a break and reassess, or adjust their protocol in consultation with a healthcare provider