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10.1073/pnas.95.18.10734 Proc Natl Acad Sci USA
Lab handling should follow established protocols for research compounds, including personal protective equipment and contamination prevention measures
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Replacement of the proximal histidine iron ligand by a cysteine or tyrosine converts heme oxygenase to an oxidase
These SCs could partially overcome the lack of appropriate animal models, faithfully recapitulating all of the clinical and pathological phenotypes of the disease, to study the mechanisms underlying PD as well as to develop translational drug development (Schule et al., 2009)
[DOI] [PMC free article] [PubMed] [Google Scholar] 90.He Y., Yue Y., Zheng X., Zhang K., Chen S., Du Z
