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B12 Deficiency Two components necessary for vitamin B12 absorption, gastric acid, and intrinsic factor, are less available or not available with the removal of all or part of the stomach

The studies summarized below are predominantly preclinical and should be interpreted accordingly

For instance, one small study demonstrated that individuals with premature hair graying had lower vitamin B12, folate, and biotin levels than control subjects without premature gray hair (13)

In published studies, the fragment has not demonstrated meaningful impact on blood glucose, insulin sensitivity, or IGF-1 concentrations at research-relevant doses