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This critical synthetic transformation occurs at carefully controlled temperatures (0-25C) and reaction times (2-6 hours) to achieve complete conversion to the best Propionyl L Carnitine, while minimizing side reactions, over-acylation, or racemization of the chiral centre essential for biological activity

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10.1016/j.cell.2008.01.030 162 ValkoA.Perez-PandolfoS.SorianelloE.BrechA.WappnerP.MelaniM

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