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U., Dong, L

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Compared to the latter, irreversible or mechanism-based inhibition is of longer duration due to the formation of strong covalent bonds and is dependent on the formation of inhibitor metabolites

For example, RHEB1 upregulation, which increases mTORC1 activity, leads to worse median survival in acute myeloid leukemia patients

Besides, the ability of LF to enter the cell nucleus is likely the primary mechanism by which it exerts its pleiotropic functions, including anticancer

Furthermore, understanding and familiarity with the drug resistance mechanisms related to the DTP also provide meaningful support for the feasibility of anti-DTP therapy