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doi: 10.3389/fphys.2022.1059369

Classically activated macrophages (M1 macrophages) mediates host defense against several bacterial, viral and protozoal pathogens and they play a role in antitumor immunity [12,13]

Michalopoulos, 2010)

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*New patients only, or those who have not been in for at least 6 months

Although this pathogen lacks catalase, which is common in prokaryotic and eukaryotic cells to combat oxidative stress, the pneumococcus relies on a unique set of proteins to manage its oxidative stress response (OSR)[3], an specialized mechanism allow it to tolerate oxidative stress and thrive in these diverse oxygen environments