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Protein-protein interactions: emerging oncotargets in the RAS-ERK pathway

100 Phase II are transferases, such as UDP-glucuronosyltransferases, sulfoctransferases, glutathione S-transferases (GSTP1) and N-acetyltransferases (NAT1)

Eur J Biochem 47:46974 Tappy L, Le KA (2010) Metabolic effects of fructose and the worldwide increase in obesity

Metal chaperones such as CQ and PBT2, which maintain metal ion homeostasis, have been shown to restore cognition, elevate zinc levels in the hippocampus, and restore levels of key proteins involved in learning/memory and synaptic plasticity in ZnT3 knockout mice