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The peripheral and central effects of amphetamines on the human nervous system are mediated primarily through their interaction with the presynaptic monoamine transporters for dopamine (DAT), serotonin (SERT) and noradrenaline (NAT)

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as well as various other nonillustrated results lay out converging evidence of sex-specific metabolic patterns

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Researchers are exploring how different ligands can stabilize distinct receptor conformations, leading to preferential activation of certain downstream signaling pathways and potentially mitigating desensitization or adverse effects