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6 Summary and prospect The present study reviews the latest research progress in the application of MSCs and MSC Exos in the treatment of male infertility induced by external factors, such as chemotherapeutic agent use, diabetes, environmental pollution, and research findings about their abilities of in vivo and in vitro differentiation into germ cells under specific conditions ( Table 2 )

For therapeutic purpose, SOD is usually injected locally

For example, phycocyanin (Li et al., 2017b) and -carboline alkaloids found in Xuelingzhi ( Polygonum aviculare , has also been shown to inhibit the NF-B pathway (Li et al., 2017b), thus reducing the secretion of ECM components and pro-inflammatory cytokines/chemokines, such as IL-6, CCL2, and CXCL1 (Li et al., 2017a)