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Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate treated rats

Gao et al., 2009a, 2010)

The roots and dried runners of the plant are traditionally used for medicinal purposes, as they contain essential phytoconstituents such as triterpenoids, saponins, glycyrrhizin, flavonoids, isoflavonoids, chalcones, coumarins, lignins, amino acids, gums, and volatile oils

Chelating Agents: Chelating agents act by forming a complex with the drug or chemical, thereby reducing its free (active) concentration: desferrioxamine for iron salts

Many solid tumors, including those from thyroid, adrenal, breast, ovarian, colon, cornea, and non-small cell lung cancer tissues, have significantly increased NQO1 expression compared to normal tissues suggesting broad potential utility for NQO1 inhibition in cancer treatment (15)