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However, etorphine, [Leu 5 ]- and [Met 5 ]-enkephalins rather promote a recycling of hDOR while DPDPE, Deltorphin I or SNC-80 induce a degradation and a down-regulation (Marie et al., 2008): when the receptor is phosphorylated by GRK2 and internalized via arrestins it can recycle whereas in a non-phosphorylated form DOR undergoes an arrestin-independent sequestration which is followed by a degradation

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Thus, requests for lower LODs and LOQs are well justified, and the evaluation of analytical methods strongly depends on these values

doi: 10.1016/j.atherosclerosis.2007.05.012

Its biological activity depends entirely on the integrity of that amino acid chain