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Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes

The double distilled water rinsed leaf sections of the same dimensions from both plants were used as control, viz., castor leaves were used as food for tobacco cutworm and bottle gourd leaves were used as food source for red pumpkin beetle assessment of bio-efficacy

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Upon ligand binding, PPAR-alpha undergoes a conformational change and associates with the nuclear receptor of 9- cis retinoic acid (RXR), forming a heterodimer that binds to PPAR-alpha responsive elements in the promoter of multiple genes associated with fatty acid metabolism, such as CPT1 (beta-oxidation), DECR2 (unsaturated fatty acid synthesis), ACAA1 (peroxisomal fatty acid oxidation) and ACADVL (beta-oxidation of very-long chain fatty acids) [23]