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B6 (Pyridoxine) Vitamin B6 is involved in brain development and function, particularly in producing neurotransmitters that regulate mood

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Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy

These early effects typically manifest as reduced morning stiffness and less intense first-step pain

This is likely because estrogen moderates the release of norepinephrine, reducing activation of the HPA axis during a stressful event