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NPI-001 is lipophilic and easily permeates cell membranes
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Batches 2 and 7 exhibited around 30 - 35 % release in 24 hrs but provided substantial release over 72 hrs
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Female homozygous B6.Cg-Fcgrttm1Dcr Tg(FcGRT)32Dcr/DcrJ mice (Tg32) aged 810 weeks (The Jackson Laboratory) (5 mice per group, 4 mice in the NaCl group) were used
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