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Aside from dietary consumption, approximately 25% of total body carnitine is synthesised by the body from the essential amino acids lysine and methionine (Vaz & Wanders 2002, Shekhawat et al

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Previous studies have highlighted the critical role of the gut microbiota in influencing the immune response and tumor progression, suggesting that altering the microbial composition could enhance the efficacy of existing treatments and mitigate resistance mechanisms

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Glutamine undergoes glutaminolysis to generate TCA cycle intermediates via glutamate production as an alternative energy source, providing pharmacological glutamine starvation as a therapeutic strategy (74, 7780)

doi: 10.1016/j.ejogrb.2016.08.026