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Reserve intestinal stem cells (rISCs) are activated in response to injury and contribute to tissue repair through the Wnt/-catenin and Notch signaling pathways

In an accelerated aging rat model, vitamin E supplementation reduced the number of nerve cells lost due to aging (La Fata et al., 2017), and improved memory and cognitive decline due to the loss of prefrontal cortical cells (Rafati et al., 2017)

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To enable selective and efficient cell type-specific drug delivery in the brain, we need to understand its cellular and molecular landscape in health and disease