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[6] During muscle contraction: H 2 O + ATP H + + ADP + P i (Mg 2+ assisted, utilization of ATP for muscle contraction by ATPase) H + + ADP + CP ATP + Creatine (Mg 2+ assisted, catalyzed by creatine kinase, ATP is used again in the above reaction for continued muscle contraction) 2 ADP ATP + AMP (catalyzed by adenylate kinase/myokinase when CP is depleted, ATP is again used for muscle contraction) Muscle at rest: ATP + Creatine H + + ADP + CP (Mg 2+ assisted, catalyzed by creatine kinase) ADP + P i ATP (during anaerobic glycolysis and oxidative phosphorylation) AMP can dephosphorylate to adenosine and diffuse out of the cell

These observations support the notion that AD is a degenerative metabolic disease in which the impairment of glucose metabolism, mediated by reduced brain glucose uptake and lowered insulin responsiveness, is closely associated with increased OS and inflammation (392)

F.Yurko-MauroK.Bailey-HallE.et al

Based on these principles, a detailed experimental protocol was prepared and submitted for ethical review