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Study participants with Parkinsons disease, who had intramuscular injections of thiamine twice per week, experienced a 49% improvement in overall function and a 55.5% decrease in fatigue

Keywords: intranasal, peptide therapeutics, IGF-1, BDNF, oxytocin, PACAP, insulin, NAP, GLP-1, NBD, NPY, GDNF, EPO 1

Those protons re-enter the matrix by traveling through a pore in ATP synthase, and the released energy is used to make ATP, increasing the ATP/ADP ratio

The tripeptide is broken down by gut peptidases and first-pass hepatic metabolism

J Biol Chem 2019;294(30):11568-78

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