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These persister cells tend to hide in immune-privileged or hard-to-reach areas of the body, such as the avascular cartilage of joints, the central nervous system, and the heart

ALA can cross the blood-brain barrier and may protect neurons from oxidative damage

This may explain why the loss of dopaminergic neurons in the SN is the main pathological feature in PD, which is significantly different from AD, in which the loss of neurons in the medial temporal lobe is dominant 25

10.1093/brain/awr039 45 DnesA.FerencziS.HalszJ.KrnyeiZ.KovcsK

Advancements in mass spectrometry-based targeted metabolomics and lipidomics: implications for clinical research

Folate intake associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease