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The conserved residues in the main channel are shown in Figure 3 including the essential histidine, a valine, and an aspartate (His82, Val123, and Asp135 in CATPO) situated 4, 8, and 12 from the heme, respectively [17]

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Although the definition of the Reference Composition provides a standard for the definition of the salinity of Standard Seawater, when considering real seawaters an additional problem arises