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Since the discovery of the NF1 gene, research has expanded into understanding the involved molecular pathways, contributing to the development of new diagnostic tools and potential therapeutic approaches

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M1 macrophages produce high levels of proinflammatory cytokines and upregulate the expression of the surface markers CD80 and CD86 [61], whereas M2 macrophages express anti-inflammatory markers and mediators, including the mannose receptors CD206 and CD163 [62]

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Meanwhile, a notable rise in the quantity of both NK and NKT cells occurs after the age of 60 (Fig

These experiments reveal the multi-faceted impact of RSL3-mediated inhibition of GPX4 in thyroid cancer cells, by altering DNA damage repair and proliferation signaling pathways, and suppressing thyroid tumor cell growth